For an oocyte to get Prepared for fertilization and expansion into an embryo, the correct list of genes must be turned on. Namekawa suspected that this pre-programming on the oocyte genome comes about in numerous phases — the main 1 starting off within the time a female is born. He believed that chromatin remodeling proteins did A lot of this perform, by shifting spools all around.
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This could assistance explain why older Women of all ages are more likely to bear kids with chromosomal Conditions like Down Syndrome, in which an extra copy of chromosome 21 finds its way into an oocyte — and later on, an embryo.
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At this point, the mobile’s DNA is packaged with a matrix of specialized proteins – leaving it primed with the very important instant, many years later on, if the egg is fertilized and starts developing into an embryo.
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